FDA Information
Bromhexine was discovered following investigation in the Asian plant Adhatoda vasica. This plant is well known in the traditional Ayurvedic medicine of India for its secretolytic action. Its dried leaves were administered as a tea against cough and asthma. The active ingredients of this plant were found to be adhatodic acid and vasicine, an alkaloid compound. Bromhexine was obtained as the synthetic derivative of vasicine.
Bromhexine was shown to have outstanding expectorant properties. It was more effective than vasicine in stimulating secretion of fluid by the mucous glands of the respiratory tract, thereby improving its clearance function. Bromhexine was developed in the research laboratories of Boehringer Ingelheim in the late 1950s as an active ingredient for pharmaceutical use.
Introduced in 1963 under the trademark Bisolvon®, bromhexine has since been appreciated as a reliable and safe secretolytic expectorant for the effective treatment of cough with phlegm.
Additionally, Bisolvon® has become one of the world's most trusted treatments for productive cough.
Please visit the official site of the FDA for further information.
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